BDBM651975 3-methyl-N-(1-(1H-pyrazol-4-yl)ethyl)-4-(((trifluoromethyl)pyridin-3-yl)methyl)-1H-pyrrole-2-carboxamide::US11903936, Compound 32

SMILES CC(NC(=O)c1[nH]cc(Cc2cccnc2C(F)(F)F)c1C)c1cn[nH]c1

InChI Key InChIKey=HCHAGNINBJAZDS-UHFFFAOYSA-N

Data  6 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 651975   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Texas

US Patent
LigandPNGBDBM651975(3-methyl-N-(1-(1H-pyrazol-4-yl)ethyl)-4-(((trifluo...)
Affinity DataIC50: 47nMAssay Description:The 50% inhibitory concentration (IC50) for the described compounds was determined using the 2,6-dichloroindophenol (DCIP) assay to monitor the DHODH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(malaria parasite P. vivax)
University of Texas

US Patent
LigandPNGBDBM651975(3-methyl-N-(1-(1H-pyrazol-4-yl)ethyl)-4-(((trifluo...)
Affinity DataIC50: 43nMAssay Description:The 50% inhibitory concentration (IC50) for the described compounds was determined using the 2,6-dichloroindophenol (DCIP) assay to monitor the DHODH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Texas

US Patent
LigandPNGBDBM651975(3-methyl-N-(1-(1H-pyrazol-4-yl)ethyl)-4-(((trifluo...)
Affinity DataIC50: 1.00E+5nMAssay Description:The 50% inhibitory concentration (IC50) for the described compounds was determined using the 2,6-dichloroindophenol (DCIP) assay to monitor the DHODH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mouse)
University of Texas

US Patent
LigandPNGBDBM651975(3-methyl-N-(1-(1H-pyrazol-4-yl)ethyl)-4-(((trifluo...)
Affinity DataIC50: 1.00E+5nMAssay Description:The 50% inhibitory concentration (IC50) for the described compounds was determined using the 2,6-dichloroindophenol (DCIP) assay to monitor the DHODH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rat)
University of Texas

US Patent
LigandPNGBDBM651975(3-methyl-N-(1-(1H-pyrazol-4-yl)ethyl)-4-(((trifluo...)
Affinity DataIC50: 1.00E+5nMAssay Description:The 50% inhibitory concentration (IC50) for the described compounds was determined using the 2,6-dichloroindophenol (DCIP) assay to monitor the DHODH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Dog)
University of Texas

US Patent
LigandPNGBDBM651975(3-methyl-N-(1-(1H-pyrazol-4-yl)ethyl)-4-(((trifluo...)
Affinity DataIC50: 1.00E+5nMAssay Description:The 50% inhibitory concentration (IC50) for the described compounds was determined using the 2,6-dichloroindophenol (DCIP) assay to monitor the DHODH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Texas

US Patent
LigandPNGBDBM651975(3-methyl-N-(1-(1H-pyrazol-4-yl)ethyl)-4-(((trifluo...)
Affinity DataEC50:  4nMAssay Description:P. falciparum 3D7 cells were grown in RPMI media supplemented with 0.5% albuMAX I, human red blood cells to 0.5% hematocrit and 0.5% parasitemia as d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate Dd2))
University of Texas

US Patent
LigandPNGBDBM651975(3-methyl-N-(1-(1H-pyrazol-4-yl)ethyl)-4-(((trifluo...)
Affinity DataEC50:  3nMAssay Description:P. falciparum 3D7 cells were grown in RPMI media supplemented with 0.5% albuMAX I, human red blood cells to 0.5% hematocrit and 0.5% parasitemia as d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
Go to US Patent