BDBM651962 US11903935, Compound IA-3

SMILES Cc1cnc(CS(=O)c2nc3ccccc3[nH]2)c(C)c1OCC(F)(F)F

InChI Key InChIKey=FPVRBOKLMQOBQO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 651962   

TargetNAD(+) hydrolase SARM1(Human)
Washington University

US Patent
LigandPNGBDBM651962(US11903935, Compound IA-3)
Affinity DataIC50: 2.14E+4nMAssay Description:Reaction mixtures were prepared on ice by mixing 10 ul of SARM1 SAM-TIR cell lysate (320 fold dilution of lysate 11-3-2016, or 80 fold lysate dilutio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent

TargetNAD(+) hydrolase SARM1(Human)
Washington University

US Patent
LigandPNGBDBM651962(US11903935, Compound IA-3)
Affinity DataIC50: 2.83E+4nMAssay Description:This assay is an adaptation of the NAD+/NADH Glo assay (Promega G9071). In this assay, NAD+ cycling enzymes convert NAD+ into NADH. In the presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
US Patent