BDBM651960 N-(1-(1H-1,2,4-triazol-3-yl) ethyl)-4-(3-fluoro-4-(trifluoromethyl)benzyl)-3-methyl-1H-pyrrole-2-carboxamide::US11903936, Compound 5

SMILES CC(NC(=O)c1[nH]cc(Cc2ccc(c(F)c2)C(F)(F)F)c1C)c1nc[nH]n1

InChI Key InChIKey=JUEHFKJXPONHOJ-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 651960   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Texas

US Patent
LigandPNGBDBM651960(N-(1-(1H-1,2,4-triazol-3-yl) ethyl)-4-(3-fluoro-4-...)
Affinity DataIC50: 110nMAssay Description:The 50% inhibitory concentration (IC50) for the described compounds was determined using the 2,6-dichloroindophenol (DCIP) assay to monitor the DHODH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(malaria parasite P. vivax)
University of Texas

US Patent
LigandPNGBDBM651960(N-(1-(1H-1,2,4-triazol-3-yl) ethyl)-4-(3-fluoro-4-...)
Affinity DataIC50: 61nMAssay Description:The 50% inhibitory concentration (IC50) for the described compounds was determined using the 2,6-dichloroindophenol (DCIP) assay to monitor the DHODH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
University of Texas

US Patent
LigandPNGBDBM651960(N-(1-(1H-1,2,4-triazol-3-yl) ethyl)-4-(3-fluoro-4-...)
Affinity DataIC50: 1.00E+5nMAssay Description:The 50% inhibitory concentration (IC50) for the described compounds was determined using the 2,6-dichloroindophenol (DCIP) assay to monitor the DHODH...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
Go to US Patent

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
University of Texas

US Patent
LigandPNGBDBM651960(N-(1-(1H-1,2,4-triazol-3-yl) ethyl)-4-(3-fluoro-4-...)
Affinity DataEC50:  39nMAssay Description:P. falciparum 3D7 cells were grown in RPMI media supplemented with 0.5% albuMAX I, human red blood cells to 0.5% hematocrit and 0.5% parasitemia as d...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
Go to US Patent