BDBM651914 US20240051956, Example 75

SMILES CC1=NC2=C(C(=O)N(C=C2C(=N1)N[C@H](C)c3cccc(c3F)C(F)F)N4CCOCC4)c5ccc(nc5)C#N

InChI Key InChIKey=HRMKBFIINYRRDO-UHFFFAOYSA-N

Data  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 651914   

TargetGTPase KRas [1-169,G12D]/Son of sevenless homolog 1 [564-1049](Human)
Qilu Regor Therapeutics

US Patent
LigandPNGBDBM651914(US20240051956, Example 75)
Affinity DataIC50: 15nMAssay Description:This assay is used to examine the potency with which compounds inhibit the protein protein interaction between SOS1 and KRAS G12D in a defined bioche...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2024
Entry Details
Go to US Patent
PDB3D3D Structure (crystal)