BDBM650751 US20240043439, Compound 43::cis-4-(4-(cyclopentylamino)phenyl)-N-(4-methyl-3- (trifluoromethyl)phenyl)-6-oxo-2,3,4,6,11,11a- hexahydro-1H-pyrido[1,2-b]isoquinoline-3-carboxamide

SMILES Cc1ccc(NC(=O)[C@H]2CC[C@@H]3Cc4ccccc4C(=O)N3C2c2ccc(NC3CCCC3)cc2)cc1C(F)(F)F

InChI Key InChIKey=GUCWPXJNYMTXNC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 650751   

TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Kira Pharmaceuticals (Suzhou)

US Patent
LigandPNGBDBM650751(cis-4-(4-(cyclopentylamino)phenyl)-N-(4-methyl-3- ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Migration assay was performed by using polycarbonate membrane with 3.0 m pore (Corning). U937/C5aR cells were collected and washed twice by PBS; cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Kira Pharmaceuticals (Suzhou)

US Patent
LigandPNGBDBM650751(cis-4-(4-(cyclopentylamino)phenyl)-N-(4-methyl-3- ...)
Affinity DataIC50: 1.00E+5nMAssay Description:U937/C5aR cells or HEK293/C5aR cells were washed by PBS and suspended in growth media at the density of 1 106 cells/ml. Seed 2 cell suspension to the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent