BDBM650738 ((2R,3S)-3-(6-(tert-butyl)-1H-benzo[d]imidazol-2-yl)-2-(4-(cyclopentylamino)phenyl)piperidin-1-yl)(2-fluoro-6-methylphenyl)methanone::US20240043439, Compound 180

SMILES Cc1cccc(F)c1C(=O)N1CCC[C@@H]([C@@H]1c1ccc(NC2CCCC2)cc1)c1nc2ccc(cc2[nH]1)C(C)(C)C

InChI Key InChIKey=CIKZJNBZZZJRDG-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 650738   

TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Kira Pharmaceuticals (Suzhou)

US Patent
LigandPNGBDBM650738(((2R,3S)-3-(6-(tert-butyl)-1H-benzo[d]imidazol-2-y...)
Affinity DataIC50: 1.00E+5nMAssay Description:U937 cells were originally obtained from the American Type Culture Collection (ATCC) and transfected with human C5a receptor (C5aR). U937/C5aR cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Kira Pharmaceuticals (Suzhou)

US Patent
LigandPNGBDBM650738(((2R,3S)-3-(6-(tert-butyl)-1H-benzo[d]imidazol-2-y...)
Affinity DataIC50: 2.55E+3nMAssay Description:Migration assay was performed by using polycarbonate membrane with 3.0 m pore (Corning). U937/C5aR cells were collected and washed twice by PBS; cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Kira Pharmaceuticals (Suzhou)

US Patent
LigandPNGBDBM650738(((2R,3S)-3-(6-(tert-butyl)-1H-benzo[d]imidazol-2-y...)
Affinity DataIC50: 1.00E+5nMAssay Description:U937/C5aR cells or HEK293/C5aR cells were washed by PBS and suspended in growth media at the density of 1 106 cells/ml. Seed 2 cell suspension to the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent