BDBM650731 US20240043439, Compound 147::cis-2-(4-(cyclopentylamino)phenyl)-1-(2-fluoro-6- methylbenzoyl)-N-(1-methyl-1H-indazol-5-yl)octahydro- 1H-cyclopenta[b]pyridine-3-carboxamide

SMILES Cc1cccc(F)c1C(=O)N1[C@H]2CCC[C@H]2CC(C1c1ccc(NC2CCCC2)cc1)C(=O)Nc1ccc2n(C)ncc2c1

InChI Key InChIKey=SEZIDNKKSXZISP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 650731   

TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Kira Pharmaceuticals (Suzhou)

US Patent
LigandPNGBDBM650731(cis-2-(4-(cyclopentylamino)phenyl)-1-(2-fluoro-6- ...)
Affinity DataIC50: 2.55E+3nMAssay Description:U937 cells were originally obtained from the American Type Culture Collection (ATCC) and transfected with human C5a receptor (C5aR). U937/C5aR cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Kira Pharmaceuticals (Suzhou)

US Patent
LigandPNGBDBM650731(cis-2-(4-(cyclopentylamino)phenyl)-1-(2-fluoro-6- ...)
Affinity DataIC50: 2.75E+4nMAssay Description:Migration assay was performed by using polycarbonate membrane with 3.0 m pore (Corning). U937/C5aR cells were collected and washed twice by PBS; cell...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Kira Pharmaceuticals (Suzhou)

US Patent
LigandPNGBDBM650731(cis-2-(4-(cyclopentylamino)phenyl)-1-(2-fluoro-6- ...)
Affinity DataIC50: 2.75E+4nMAssay Description:U937/C5aR cells or HEK293/C5aR cells were washed by PBS and suspended in growth media at the density of 1 106 cells/ml. Seed 2 cell suspension to the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent