BDBM650685 US20240043439, Compound 71::cis-2-(4-(cyclopentylamino)phenyl)-N-(2,3- dihydrobenzo[b][1,4]dioxin-6-yl)-1-(2-fluoro-6- methylbenzoyl)octahydro-1H-cyclopenta[b]pyridine-3- carboxamide

SMILES Cc1cccc(F)c1C(=O)N1[C@H]2CCC[C@H]2CC(C1c1ccc(NC2CCCC2)cc1)C(=O)Nc1ccc2OCCOc2c1

InChI Key InChIKey=WMQNAERJQBQKBF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 650685   

TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Kira Pharmaceuticals (Suzhou)

US Patent
LigandPNGBDBM650685(cis-2-(4-(cyclopentylamino)phenyl)-N-(2,3- dihydro...)
Affinity DataIC50: 2.55E+3nMAssay Description:U937 cells were originally obtained from the American Type Culture Collection (ATCC) and transfected with human C5a receptor (C5aR). U937/C5aR cells ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetC5a anaphylatoxin chemotactic receptor 1(Human)
Kira Pharmaceuticals (Suzhou)

US Patent
LigandPNGBDBM650685(cis-2-(4-(cyclopentylamino)phenyl)-N-(2,3- dihydro...)
Affinity DataIC50: 1.00E+5nMAssay Description:U937/C5aR cells or HEK293/C5aR cells were washed by PBS and suspended in growth media at the density of 1 106 cells/ml. Seed 2 cell suspension to the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent