BDBM649901 US20240043405, Compound 027

SMILES C=CC(=O)N1CCC[C@@H](C1)C(=O)Nc1ccc(NC(=O)c2cccc(n2)-c2ccn[nH]2)nc1

InChI Key InChIKey=IAQIZJLJAOFQPG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 649901   

TargetInterleukin-1 receptor-associated kinase 1(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM649901(US20240043405, Compound 027)
Affinity DataIC50: 6.37nMAssay Description:To measure the IC50 values of the compounds herein against IRAK1, the Adapta Universal Kinase Assay (ThermoFisher) was used. Briefly, 100 nL of diffe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
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TargetInterleukin-1 receptor-associated kinase 4(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM649901(US20240043405, Compound 027)
Affinity DataIC50: 1.87E+3nMAssay Description:To measure the IC50 values of compounds herein against IRAK4, a Z′-LYTE assay (ThermoFisher) was used. Briefly, 2.5 μL. of different conce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent