BDBM6497 6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin-4-amine::CHEMBL543904::RPR-108518A

SMILES COc1cc2ncnc(Nc3cc(OC)c(OC)c(OC)c3)c2cc1OC

InChI Key InChIKey=RNCVPFCGSMNPPO-UHFFFAOYSA-N

Data  9 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 6497   

TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth-Ayerst Research

LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)
Affinity DataIC50: 280nMpH: 7.5 T: 2°CAssay Description:Src kinase activity was measured in an ELISA format. IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the tra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/15/2005
Entry Details Article
PubMed
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonism towards Colony stimulating factor 1 receptor (CSF-1R)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetTyrosine-protein kinase Lck(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)
Affinity DataIC50: 500nMAssay Description:Inhibition of p56 lck tyrosine kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)
Affinity DataIC50: 500nMAssay Description:Antagonism towards Epidermal growth factor receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetTyrosine-protein kinase Lck(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)
Affinity DataIC50: 500nMAssay Description:Inhibition of p56lck kinase autophosphorylation in Jurkat cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article

TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)
Affinity DataIC50: 500nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation, 0.05-0.10More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article

LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of platelet-derived growth factor receptor (PDGF-R)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2010
Entry Details Article

TargetCyclin-G-associated kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)
Affinity DataKd:  10nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)
Affinity DataKd:  22nMAssay Description:Binding affinity to wild-type human partial length EGFR (R669 to V1011 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of EGFR in human A431 cells assessed as reduction in EGF-stimulated EGFR autophosphorylation preincuabted for 90 mins followed by EGF-stim...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed
TargetCyclin-G-associated kinase(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM6497(6,7-dimethoxy-N-(3,4,5-trimethoxyphenyl)quinazolin...)
Affinity DataIC50: 350nMAssay Description:Inhibition of tracer 5 binding to human N-terminal nano luciferase-fused GAK expressed in HEK293 cells measured after 2 hrs by nanoBRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2021
Entry Details Article
PubMed