BDBM649658 US20240042050, Example PhBz-1::US20240042050, Example PhBz-12::US20240042050, Example PhBz-14::US20240042050, Example PhBz-15

SMILES CCCNC(=O)C1=Cc2ccc(cc2N=C(N)C1)-c1cccc(c1)S(=O)(=O)N1CC(CN)C1

InChI Key InChIKey=SXNAMMMHSIOZHO-UHFFFAOYSA-N

Data  8 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 649658   

TargetToll-like receptor 7(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM649658(US20240042050, Example PhBz-1 | US20240042050, Exa...)
Affinity DataEC50:  3.93E+3nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetToll-like receptor 8(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM649658(US20240042050, Example PhBz-1 | US20240042050, Exa...)
Affinity DataEC50:  461nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetToll-like receptor 7(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM649658(US20240042050, Example PhBz-1 | US20240042050, Exa...)
Affinity DataEC50:  738nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetToll-like receptor 8(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM649658(US20240042050, Example PhBz-1 | US20240042050, Exa...)
Affinity DataEC50:  163nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetToll-like receptor 7(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM649658(US20240042050, Example PhBz-1 | US20240042050, Exa...)
Affinity DataEC50:  9.00E+3nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetToll-like receptor 8(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM649658(US20240042050, Example PhBz-1 | US20240042050, Exa...)
Affinity DataEC50:  4.66E+3nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetToll-like receptor 7(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM649658(US20240042050, Example PhBz-1 | US20240042050, Exa...)
Affinity DataEC50:  9.00E+3nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent

TargetToll-like receptor 8(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM649658(US20240042050, Example PhBz-1 | US20240042050, Exa...)
Affinity DataEC50:  3.61E+3nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2024
Entry Details
Go to US Patent