BDBM649587 Benzo[d]isoxazol-3-yl((5R,9S)-2-methyl-3-(1-methyl-3- (trifluoromethyl)-1H-pyrazol-5-yl)-4,5,6,7,8,9-hexahydro-2H-5,9- epiminocycloocta[c]pyrazol-10-yl)methanone::US11891387, Example 84

SMILES Cn1nc(cc1-c1c2C[C@@H]3CCC[C@@H](N3C(=O)c3noc4ccccc34)c2nn1C)C(F)(F)F

InChI Key InChIKey=ZPHUMUGXOVEIRK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 649587   

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM649587(Benzo[d]isoxazol-3-yl((5R,9S)-2-methyl-3-(1-methyl...)
Affinity DataIC50: 5.10nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2024
Entry Details
Go to US Patent