BDBM649582 (3-Methoxy-2-methylphenyl)((5R,9S)-2-methyl-3-(1-methyl-5- (trifluoromethyl)-1H-pyrazol-3-yl)-4,5,6,7,8,9-hexahydro-2H-5,9- epiminocycloocta[c]pyrazol-10-yl)methanone::US11891387, Example 79

SMILES COc1cccc(C(=O)N2[C@H]3CCC[C@@H]2c2nn(C)c(-c4cc(n(C)n4)C(F)(F)F)c2C3)c1C

InChI Key InChIKey=RHZZMVVGSLELHD-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 649582   

TargetMonoglyceride lipase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM649582((3-Methoxy-2-methylphenyl)((5R,9S)-2-methyl-3-(1-m...)
Affinity DataIC50: 16nMAssay Description:The assay used to measure the in vitro activity of MGL is adapted from the assay used for another serine hydrolase (FAAH) described in Wilson et al.,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/8/2024
Entry Details
Go to US Patent