BDBM649282 N-(2-{4-[(1,3-Benzothiazol-2-yloxy)methyl]piperidin-1-yl}-2-[4-::US20240034737, Example 93

SMILES FC(F)c1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(COc2nc3ccccc3s2)CC1

InChI Key InChIKey=HWHMHCSCRIJBSB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 649282   

TargetP2X purinoceptor 7(Human)
Breye Therapeutics

US Patent
LigandPNGBDBM649282(N-(2-{4-[(1,3-Benzothiazol-2-yloxy)methyl]piperidi...)
Affinity DataIC50: 43.6nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Breye Therapeutics

US Patent
LigandPNGBDBM649282(N-(2-{4-[(1,3-Benzothiazol-2-yloxy)methyl]piperidi...)
Affinity DataIC50: 22.7nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent