BDBM649268 2-Chloro-N-(2-{4-[(6-chloropyridin-2-yl)oxy]piperidin-1-yl}-2-[4-::US20240034737, Example 77
SMILES FC(F)c1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1cccc(Cl)n1
InChI Key InChIKey=QKVOLMVFNFQLNU-UHFFFAOYSA-N
Data 6 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 649268
Affinity DataIC50: 11.1nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
Affinity DataIC50: 13.4nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Antagonist activity at human P2X7 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Antagonist activity at mouse P2X7 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human P2X7 receptor expressed in HEK293 cells incubated for 5 mins followed by Bz-ATP addition measured after 3 mins by fluorescence ba...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of mouse P2X7 receptor expressed in HEK293 cells incubated for 5 mins followed by Bz-ATP addition measured after 3 mins by fluorescence ba...More data for this Ligand-Target Pair