BDBM649252 2-Chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl]-2-{4-[(2-fluoro-6-::US20240034737, Example 54

SMILES Cc1cc(OC2CCN(CC2)C(CNC(=O)c2c(F)cccc2Cl)c2scnc2C(F)F)nc(F)n1

InChI Key InChIKey=AOKDJGLMRIIXPU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 649252   

TargetP2X purinoceptor 7(Human)
Breye Therapeutics

US Patent
LigandPNGBDBM649252(2-Chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Affinity DataIC50: 22.8nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Breye Therapeutics

US Patent
LigandPNGBDBM649252(2-Chloro-N-{2-[4-(difluoromethyl)-1,3-thiazol-5-yl...)
Affinity DataIC50: 52.9nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent