BDBM649223 N-{2-[4-(1,3-Benzoxazol-2-yloxy)piperidin-1-yl]-2-[4-(difluoromethyl)-::US20240034737, Example 22

SMILES FC(F)c1ncsc1C(CNC(=O)c1c(F)cccc1Cl)N1CCC(CC1)Oc1nc2ccccc2o1

InChI Key InChIKey=XJNZQQLEIXCUCG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 649223   

TargetP2X purinoceptor 7(Human)
Breye Therapeutics

US Patent
LigandPNGBDBM649223(N-{2-[4-(1,3-Benzoxazol-2-yloxy)piperidin-1-yl]-2-...)
Affinity DataIC50: 20.5nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Mouse)
Breye Therapeutics

US Patent
LigandPNGBDBM649223(N-{2-[4-(1,3-Benzoxazol-2-yloxy)piperidin-1-yl]-2-...)
Affinity DataIC50: 12.3nMAssay Description:Extracellular binding of Bz-ATP to P2X7 receptor opens the channel and allows Ca2+ influx into the cells. This Ca2+ entry was measured in HEK-293 cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent