BDBM648443 US20240033370, Hx No. CycBz-15::US20240033370, Hx No. CycBz-22::US20240033370, Hx No. CycBz-5

SMILES CCCNC(=O)C1=Cc2ccc(cc2N=C(N)C1)-c1cnc(CN)nc1

InChI Key InChIKey=LGBKNDFSDYWYKO-UHFFFAOYSA-N

Data  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 648443   

TargetToll-like receptor 7(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM648443(US20240033370, Hx No. CycBz-5 | US20240033370, Hx ...)
Affinity DataEC50:  525nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetToll-like receptor 8(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM648443(US20240033370, Hx No. CycBz-5 | US20240033370, Hx ...)
Affinity DataEC50:  17nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetToll-like receptor 7(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM648443(US20240033370, Hx No. CycBz-5 | US20240033370, Hx ...)
Affinity DataEC50:  35nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetToll-like receptor 8(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM648443(US20240033370, Hx No. CycBz-5 | US20240033370, Hx ...)
Affinity DataEC50:  10nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetToll-like receptor 7(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM648443(US20240033370, Hx No. CycBz-5 | US20240033370, Hx ...)
Affinity DataEC50:  3.92E+3nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent

TargetToll-like receptor 8(Human)
Bolt Biotherapeutics

US Patent
LigandPNGBDBM648443(US20240033370, Hx No. CycBz-5 | US20240033370, Hx ...)
Affinity DataEC50:  1.15E+3nMAssay Description:HEK293 reporter cells expressing human TLR7 or human TLR8 were purchased from Invivogen and vendor protocols were followed for cellular propagation a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2024
Entry Details
Go to US Patent