BDBM647933 US20240025919, Compound 168

SMILES C[C@@H]1CN(CC2(COc3nc4N5C[C@H]6CC[C@H](N6)[C@H]5[C@H](C)Oc5nc(c(F)c(n3)c45)-c3cc(N)c(F)c(C)c3C(F)(F)F)CC2)CCO1

InChI Key InChIKey=XBKKLTJBLJXEOO-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 647933   

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM647933(US20240025919, Compound 168)
Affinity DataIC50: 0.120nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1I-mediated nucleotide exchange in KRAS G121D. In this assay, the SOS1-pro...More data for this Ligand-Target Pair
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Date in BDB:
3/19/2024
Entry Details
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