BDBM647931 US20240025919, Compound 166

SMILES C[C@@H]1Oc2nc(c(F)c3nc(OC[C@]4(CN5C[C@H]6C[C@@H]5CO6)CC4(F)F)nc(N4C[C@H]5CC[C@H](N5)[C@@H]14)c23)-c1cc(N)c(F)c(C)c1C(F)(F)F

InChI Key InChIKey=GIJGFSZKANCUTK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 647931   

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM647931(US20240025919, Compound 166)
Affinity DataIC50: 0.100nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1I-mediated nucleotide exchange in KRAS G121D. In this assay, the SOS1-pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM647931(US20240025919, Compound 166)
Affinity DataIC50: 0.150nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1I-mediated nucleotide exchange in KRAS G121D. In this assay, the SOS1-pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent