BDBM647894 US20240025919, Compound 126

SMILES C[C@@H]1Oc2nc(c(F)c3nc(OC[C@]45CCC[C@@H]4N(C)CCC5)nc(N4C[C@H]5CC[C@H](N5)[C@@H]14)c23)-c1cc(N)c(F)c(C)c1C(F)(F)F

InChI Key InChIKey=DEVXGMQEBFFSAK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 647894   

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM647894(US20240025919, Compound 126)
Affinity DataIC50: 0.100nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1I-mediated nucleotide exchange in KRAS G121D. In this assay, the SOS1-pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM647894(US20240025919, Compound 126)
Affinity DataIC50: 0.370nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1I-mediated nucleotide exchange in KRAS G121D. In this assay, the SOS1-pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM647894(US20240025919, Compound 126)
Affinity DataIC50: 0.370nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1I-mediated nucleotide exchange in KRAS G121D. In this assay, the SOS1-pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent

TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM647894(US20240025919, Compound 126)
Affinity DataIC50: 0.370nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1I-mediated nucleotide exchange in KRAS G121D. In this assay, the SOS1-pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent