BDBM647783 US20240025919, Compound 10

SMILES CCc1cccc2cc(O)cc(-c3nc4O[C@@H](C)[C@@H]5[C@@H]6CC[C@H](CN5c5nc(OC[C@@]78CCCN7C[C@H](F)C8)nc(c3F)c45)N6)c12

InChI Key InChIKey=NDBYHQQTABNAEN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 647783   

TargetGTPase KRas(Human)
Genentech

US Patent
LigandPNGBDBM647783(US20240025919, Compound 10)
Affinity DataIC50: 6.46nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1-mediated nucleotide exchange in KRAS WT. In this assay, the SOS1-promote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
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TargetGTPase KRas [G12D](Human)
Genentech

US Patent
LigandPNGBDBM647783(US20240025919, Compound 10)
Affinity DataIC50: 0.0820nMAssay Description:Biochemical compound potencies are assessed by evaluating inhibition of SOS1I-mediated nucleotide exchange in KRAS G121D. In this assay, the SOS1-pro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent