BDBM647761 (S)-3-(5-(3,5-difluoro-4- methylphenyl)-3-oxo-6,7-dihydro-3H- pyrrolo[2,1-c][1,2,4]triazol-2(5H)- yl)bicyclo[1.1.1]pentane-1-carbonitrile::US20240025912, Compound 1-51

SMILES Cc1c(F)cc(cc1F)[C@@H]1CCc2nn(c(=O)n12)C12CC(C1)(C2)C#N

InChI Key InChIKey=UGPUZRTTYHJLJH-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 647761   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM647761(US20240025912, Compound 1-51 | (S)-3-(5-(3,5-diflu...)
Affinity DataEC50:  16.1nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM647761(US20240025912, Compound 1-51 | (S)-3-(5-(3,5-diflu...)
Affinity DataEC50:  16nMAssay Description:Inhibition of recombinant GST tagged RIPK1 (1 to 327 residues) (unknown origin) expressed in baculovirus transfected Sf21 cells using dephosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed