BDBM647724 (S)-5-(3-fluoro-5-methylphenyl)-2-(3- fluorobicyclo[1.1.1]pentan-1-yl)- 2,5,6,7-tetrahydro-3H-pyrrolo[2,1- c][1,2,4]triazol-3-one::US20240025912, Compound 4-9

SMILES Cc1cc(F)cc(c1)[C@@H]1CCc2nn(c(=O)n12)C12CC(F)(C1)C2

InChI Key InChIKey=JQAWVYFVGDCWMX-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 647724   

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM647724(US20240025912, Compound 4-9 | (S)-5-(3-fluoro-5-me...)
Affinity DataEC50:  17nMAssay Description:In this assay, the potency (EC50) of each compound was determined from a ten-point (1:3 serial dilution; top compound concentration of 100000 nM) tit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent

TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM647724(US20240025912, Compound 4-9 | (S)-5-(3-fluoro-5-me...)
Affinity DataEC50:  17nMAssay Description:Inhibition of recombinant GST tagged RIPK1 (1 to 327 residues) (unknown origin) expressed in baculovirus transfected Sf21 cells using dephosphorylate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed