BDBM647305 US20240025892, Example 12

SMILES COCCN1CCC11CCN(CC1)c1cccc2ccc(nc12)-n1cnc2cc(OCC3(C)COC3)ccc12

InChI Key InChIKey=XPJFDYHVVLGXHY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 647305   

TargetSerine/threonine-protein kinase SIK2(Human)
The General Hospital

US Patent
LigandPNGBDBM647305(US20240025892, Example 12)
Affinity DataIC50: 4.90nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
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TargetSerine/threonine-protein kinase SIK3(Human)
The General Hospital

US Patent
LigandPNGBDBM647305(US20240025892, Example 12)
Affinity DataIC50: 11.9nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase SIK1(Human)
The General Hospital

US Patent
LigandPNGBDBM647305(US20240025892, Example 12)
Affinity DataIC50: 140nMAssay Description:Assays were performed in base reaction buffer (20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/mL BSA, 0.1 mM Na3VO4, 2 mM DTT, 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2024
Entry Details
Go to US Patent