BDBM645850 (R)-2-chloro-N-(5-chloro-2-methoxy-6-(2H-1,2,3-triazol-2-yl)pyridin-3-yl)-8-methyl-8-(trifluoromethyl)-7,8-dihydro-6H-pyrazolo[1,5-a]pyrrolo[2,3-e]pyrimidine-6-carboxamide::US20240018157, Example 52

SMILES COc1nc(N\N=C/C=N)c(Cl)cc1NC(=O)N1C[C@](C)(c2c1cnc1cc(Cl)nn21)C(F)(F)F

InChI Key InChIKey=PULWHZZDGSOFNY-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 645850   

LigandPNGBDBM645850(US20240018157, Example 52 | (R)-2-chloro-N-(5-chlo...)
Affinity DataIC50: 10nMAssay Description:The final assay buffer includes 2 nM of MALT1 full-length protein, 50 μM Ac-LRSR-AMC substrate, 50 mM Tris pH 7.5, 600 mM Sodium Citrate, 1 mM D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent