BDBM645827 (R)-2-chloro-N-(5-chloro-6-(4-((dimethylamino)methyl)-2H-1,2,3-triazol-2-yl)pyridin-3-yl)-8-methyl-8-(trifluormethyl)-7,8-dihydro-6H-pyrazolo[15-a]pyrrolo[2,3-e]pyrimidine-6-carboxamide::US20240018157, Example 29

SMILES CN(C)Cc1cnn(n1)-c1ncc(NC(=O)N2C[C@](C)(c3c2cnc2cc(Cl)nn32)C(F)(F)F)cc1Cl

InChI Key InChIKey=UCDLZEACXQRNAS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 645827   

LigandPNGBDBM645827(US20240018157, Example 29 | (R)-2-chloro-N-(5-chlo...)
Affinity DataIC50: 10nMAssay Description:The final assay buffer includes 2 nM of MALT1 full-length protein, 50 μM Ac-LRSR-AMC substrate, 50 mM Tris pH 7.5, 600 mM Sodium Citrate, 1 mM D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
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LigandPNGBDBM645827(US20240018157, Example 29 | (R)-2-chloro-N-(5-chlo...)
Affinity DataIC50: 55nMAssay Description:The final assay buffer includes 1 nM of MALT1 full-length protein, 50 μM Ac-LRSR-AMC substrate, 50 mM Tris pH 7.5, 600 mM Sodium Citrate, 1 mM D...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent