BDBM645781 US20240018153, Compound I-53

SMILES COCCOc1ccc(Nc2ncc(F)c(Nc3cccc(NS(=O)(=O)c4c(F)c(F)c(F)c(F)c4C(F)(F)F)c3)n2)cc1

InChI Key InChIKey=VDNVMXBESHFVLU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 645781   

TargetTyrosine-protein kinase BTK(Human)
2692372 Ontario

US Patent
LigandPNGBDBM645781(US20240018153, Compound I-53)
Affinity DataIC50: 10nMAssay Description:BTK Kinase activity was monitored using a HTRF KinEASE-TK kit from Cisbio (62TK0PEC). For BTK, the 1 kinase buffer was supplemented with 10 mM MnCl2,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
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TargetTyrosine-protein kinase JAK3(Human)
2692372 Ontario

US Patent
LigandPNGBDBM645781(US20240018153, Compound I-53)
Affinity DataIC50: 10nMAssay Description:JAK3 Kinase activity was monitored using a HTRF KinEASE-TK kit from Cisbio (62TK0PEC). The buffer used was 1 kinase buffer supplemented with 2 mM MnC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent

TargetFibroblast growth factor receptor 4(Human)
2692372 Ontario

US Patent
LigandPNGBDBM645781(US20240018153, Compound I-53)
Affinity DataIC50: 10nMAssay Description:FGFR4 Kinase activity was monitored using a HTRF KinEASE-TK kit from Cisbio (62TK0PEC). The buffer used was 1 kinase buffer supplemented with 2 mM Mn...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent