BDBM645780 US20240018153, Compound I-50

SMILES CS(=O)(=O)c1c(F)c(F)c(F)c(F)c1CNCCNc1ncnc2[nH]ccc12

InChI Key InChIKey=QGLIBKMGOZTBQZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 645780   

TargetTyrosine-protein kinase BTK(Human)
2692372 Ontario

US Patent
LigandPNGBDBM645780(US20240018153, Compound I-50)
Affinity DataIC50: 10nMAssay Description:BTK Kinase activity was monitored using a HTRF KinEASE-TK kit from Cisbio (62TK0PEC). For BTK, the 1 kinase buffer was supplemented with 10 mM MnCl2,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
2692372 Ontario

US Patent
LigandPNGBDBM645780(US20240018153, Compound I-50)
Affinity DataIC50: 10nMAssay Description:BMX Kinase activity was monitored using a HTRF KinEASE-TK kit from Cisbio (62TK0PEC). The buffer used was 1 kinase buffer supplemented with 2 mM MnCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
2692372 Ontario

US Patent
LigandPNGBDBM645780(US20240018153, Compound I-50)
Affinity DataIC50: 255nMAssay Description:JAK3 Kinase activity was monitored using a HTRF KinEASE-TK kit from Cisbio (62TK0PEC). The buffer used was 1 kinase buffer supplemented with 2 mM MnC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent