BDBM645774 US20240018153, Compound I-32

SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CN(C1)C(=O)c1c(F)c(F)c(F)c(F)c1S(N)(=O)=O

InChI Key InChIKey=KAPOYVHWAZSCME-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 645774   

TargetTyrosine-protein kinase BTK(Human)
2692372 Ontario

US Patent
LigandPNGBDBM645774(US20240018153, Compound I-32)
Affinity DataIC50: 10nMAssay Description:BTK Kinase activity was monitored using a HTRF KinEASE-TK kit from Cisbio (62TK0PEC). For BTK, the 1 kinase buffer was supplemented with 10 mM MnCl2,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
2692372 Ontario

US Patent
LigandPNGBDBM645774(US20240018153, Compound I-32)
Affinity DataIC50: 10nMAssay Description:JAK3 Kinase activity was monitored using a HTRF KinEASE-TK kit from Cisbio (62TK0PEC). The buffer used was 1 kinase buffer supplemented with 2 mM MnC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent