BDBM645768 US20240018153, Compound I-37

SMILES C[S@](=O)c1c(F)c(F)c(F)c(F)c1C(=O)N1CC(C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12

InChI Key InChIKey=QGJCMFMKZTYYKC-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 645768   

TargetEpidermal growth factor receptor(Human)
2692372 Ontario

US Patent
LigandPNGBDBM645768(US20240018153, Compound I-37)
Affinity DataIC50: 10nMAssay Description:EGFR Kinase activity was monitored using a HTRF KinEASE-TK kit from Cisbio (62TK0PEC). The buffer used was 1 kinase buffer supplemented with 2 mM MnC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
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TargetTyrosine-protein kinase BTK(Human)
2692372 Ontario

US Patent
LigandPNGBDBM645768(US20240018153, Compound I-37)
Affinity DataIC50: 10nMAssay Description:BTK Kinase activity was monitored using a HTRF KinEASE-TK kit from Cisbio (62TK0PEC). For BTK, the 1 kinase buffer was supplemented with 10 mM MnCl2,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent

TargetCytoplasmic tyrosine-protein kinase BMX(Human)
2692372 Ontario

US Patent
LigandPNGBDBM645768(US20240018153, Compound I-37)
Affinity DataIC50: 10nMAssay Description:BMX Kinase activity was monitored using a HTRF KinEASE-TK kit from Cisbio (62TK0PEC). The buffer used was 1 kinase buffer supplemented with 2 mM MnCl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3(Human)
2692372 Ontario

US Patent
LigandPNGBDBM645768(US20240018153, Compound I-37)
Affinity DataIC50: 255nMAssay Description:JAK3 Kinase activity was monitored using a HTRF KinEASE-TK kit from Cisbio (62TK0PEC). The buffer used was 1 kinase buffer supplemented with 2 mM MnC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent