BDBM645765 US20240018153, Compound I-27

SMILES CS(=O)(=O)c1c(F)c(F)c(F)c(F)c1C(=O)N1CC(C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)ncnc12

InChI Key InChIKey=OEWXDDMSLZROGF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 645765   

TargetEpidermal growth factor receptor(Human)
2692372 Ontario

US Patent
LigandPNGBDBM645765(US20240018153, Compound I-27)
Affinity DataIC50: 10nMAssay Description:EGFR Kinase activity was monitored using a HTRF KinEASE-TK kit from Cisbio (62TK0PEC). The buffer used was 1 kinase buffer supplemented with 2 mM MnC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
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TargetTyrosine-protein kinase JAK3(Human)
2692372 Ontario

US Patent
LigandPNGBDBM645765(US20240018153, Compound I-27)
Affinity DataIC50: 10nMAssay Description:JAK3 Kinase activity was monitored using a HTRF KinEASE-TK kit from Cisbio (62TK0PEC). The buffer used was 1 kinase buffer supplemented with 2 mM MnC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent