BDBM645742 US20240018140, Compound 83::trans-N-(5-fluoro-8-(2-(2,2,2- trifluoroethoxy)phenyl)quinolin-2- yl)-3-hydroxycyclobutane-1- carboxamide

SMILES O[C@H]1C[C@@H](C1)C(=O)Nc1ccc2c(F)ccc(-c3ccccc3OCC(F)(F)F)c2n1

InChI Key InChIKey=DOZKHWXJANOFSK-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 645742   

TargetCeramide glucosyltransferase(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM645742(US20240018140, Compound 83 | trans-N-(5-fluoro-8-(...)
Affinity DataEC50:  6.90nMAssay Description:Using Promega's UDP-Glo Glycosyltransferase assay kit (Promega Corporation, Madison, WI, USA (Promega)), GCS activity was indirectly measured by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
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