BDBM645444 US20240018122, Example 109::methyl N-[2-(4-{[(4-{[6-(5- chloro-2-fluorophenyl)-3- methylpyridazin-4- yl]amino}pyridin-2-yl) carbamoyl]methyl}piperazin- 1-yl)ethyl]carbamate

SMILES COC(=O)NCCN1CCN(CC(=O)Nc2cc(Nc3cc(nnc3C)-c3cc(Cl)ccc3F)ccn2)CC1

InChI Key InChIKey=QMWNIIATABPKFJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 645444   

TargetTGF-beta receptor type-1(Human)
Chiesi Farmaceutici

US Patent
LigandPNGBDBM645444(US20240018122, Example 109 | methyl N-[2-(4-{[(4-{...)
Affinity DataIC50: 1nMAssay Description:The enzymatic activity of compounds of the present invention was monitored measuring the formation of ADP using the ADP-GLO Kinases assay. Following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Chiesi Farmaceutici

US Patent
LigandPNGBDBM645444(US20240018122, Example 109 | methyl N-[2-(4-{[(4-{...)
Affinity DataIC50: 1nMAssay Description:The enzymatic activity of compounds of the present invention was monitored measuring the formation of ADP using the ADP-GLO Kinases assay. Following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent