BDBM645431 US20240018122, Example 94::methyl 4-{2-[(4-{[6-(5- chloro-2-fluorophenyl)-3- methylpyridazin-4- yl]amino}pyridin-2- yl)carbamoyl]ethyl}-1- methylpiperazine-2- carboxylate

SMILES COC(=O)C1CN(CCC(=O)Nc2cc(Nc3cc(nnc3C)-c3cc(Cl)ccc3F)ccn2)CCN1C

InChI Key InChIKey=UMZWVXKLTHVELV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 645431   

TargetTGF-beta receptor type-1(Human)
Chiesi Farmaceutici

US Patent
LigandPNGBDBM645431(US20240018122, Example 94 | methyl 4-{2-[(4-{[6-(5...)
Affinity DataIC50: 1nMAssay Description:The enzymatic activity of compounds of the present invention was monitored measuring the formation of ADP using the ADP-GLO Kinases assay. Following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent

TargetTGF-beta receptor type-1(Human)
Chiesi Farmaceutici

US Patent
LigandPNGBDBM645431(US20240018122, Example 94 | methyl 4-{2-[(4-{[6-(5...)
Affinity DataIC50: 1nMAssay Description:The enzymatic activity of compounds of the present invention was monitored measuring the formation of ADP using the ADP-GLO Kinases assay. Following ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent