BDBM645378 US20240016810, Compound TABLE 15.3::US20240016810, Compound TABLE 16.11::US20240150358, Example 00177::US20240208964, Biochemistry b3::US20250145642, Compound LastTbl.11::US20250197375, Compound Fig.7.11

SMILES Cc1cccc(\C=N\Nc2nc(N3CCOCC3)c3nc(-c4ccncc4)n(C)c3n2)c1

InChI Key InChIKey=LSFCNGZUCAAZTL-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 645378   

LigandPNGBDBM645378(US20240016810, Compound TABLE 16.11 | US2024001681...)
Affinity DataIC50: 4.90nMAssay Description:The biochemical PIKFyve inhibition assays were run by Carna Biosciences according to proprietary methodology based on the Promega ADP-Glo Kinase assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent

LigandPNGBDBM645378(US20240016810, Compound TABLE 16.11 | US2024001681...)
Affinity DataIC50: 5nMAssay Description:The biochemical PIKFyve inhibition assays were run by Carna Biosciences according to proprietary methodology based on the Promega ADP-Glo Kinase assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2024
Entry Details
Go to US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Kineta

US Patent
LigandPNGBDBM645378(US20240016810, Compound TABLE 16.11 | US2024001681...)
Affinity DataIC50: 4.90nMAssay Description:The biochemical PIKFyve inhibition assays were run by Carna Biosciences according to proprietary methodology based on the Promega ADP-Glo Kinase assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Kineta

US Patent
LigandPNGBDBM645378(US20240016810, Compound TABLE 16.11 | US2024001681...)
Affinity DataIC50: 5nMAssay Description:The biochemical PIKFyve inhibition assays were run by Carna Biosciences according to proprietary methodology based on the Promega ADP-Glo Kinase assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2024
Entry Details
Go to US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Kineta

US Patent
LigandPNGBDBM645378(US20240016810, Compound TABLE 16.11 | US2024001681...)
Affinity DataIC50: 1nMAssay Description:The biochemical PIKFyve inhibition assays were run by Carna Biosciences according to proprietary methodology based on the Promega ADP-Glo Kinase assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Kineta

US Patent
LigandPNGBDBM645378(US20240016810, Compound TABLE 16.11 | US2024001681...)
Affinity DataIC50: 5nMAssay Description:The biochemical PIKFyve inhibition assays were run by Carna Biosciences according to proprietary methodology based on the Promega ADP-Glo Kinase assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/9/2024
Entry Details
Go to US Patent

Target1-phosphatidylinositol 3-phosphate 5-kinase(Human)
Kineta

US Patent
LigandPNGBDBM645378(US20240016810, Compound TABLE 16.11 | US2024001681...)
In Depth
Date in BDB:
9/9/2025
Entry Details
Go to US Patent

LigandPNGBDBM645378(US20240016810, Compound TABLE 16.11 | US2024001681...)
Affinity DataIC50: 4.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2025
Entry Details
Go to US Patent

LigandPNGBDBM645378(US20240016810, Compound TABLE 16.11 | US2024001681...)
In Depth
Date in BDB:
10/14/2025
Entry Details
Go to US Patent

LigandPNGBDBM645378(US20240016810, Compound TABLE 16.11 | US2024001681...)
Affinity DataIC50: 4.72E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/14/2025
Entry Details
Go to US Patent