BDBM645229 6-(2-((3-fluorooxetan-3- yl)methoxy)pyrimidin-5- yl)-2((5-fluoropyridin-3- yl)methyl)pyridazine- 3(2H)-one::US11873290, Compound 66

SMILES Fc1cncc(Cn2nc(ccc2=O)-c2cnc(OCC3(F)COC3)nc2)c1

InChI Key InChIKey=GXKJODIRSLXNHO-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 645229   

TargetDystrophin(Human)
Edgewise Therapeutics

US Patent
LigandPNGBDBM645229(US11873290, Compound 66 | 6-(2-((3-fluorooxetan-3-...)
Affinity DataIC50: 1.00E+4nMAssay Description:BSA, ATP, NADH, PEP, and DTT solutions were thawed at room temperature, then transferred to ice. Pellet-frozen myofibrils (approximately twice the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2024
Entry Details
Go to US Patent

TargetDystrophin(Human)
Edgewise Therapeutics

US Patent
LigandPNGBDBM645229(US11873290, Compound 66 | 6-(2-((3-fluorooxetan-3-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Following example 15, the counter screen was done using frozen myofibril pellets obtained from cardiac tissue. The assay was done in the same manner ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2024
Entry Details
Go to US Patent