BDBM645221 2-((3- (methoxymethyl)isoxazol- 5-yl)methyl)-6-(2-(2,2,2- trifluoroethoxy)pyrimidin- 5-yl)pyridazin-3(2H)-one::US11873290, Compound 56

SMILES COCc1cc(Cn2nc(ccc2=O)-c2cnc(OCC(F)(F)F)nc2)on1

InChI Key InChIKey=LGUCPGKVGMTAEX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 645221   

TargetDystrophin(Human)
Edgewise Therapeutics

US Patent
LigandPNGBDBM645221(US11873290, Compound 56 | 2-((3- (methoxymethyl)is...)
Affinity DataIC50: 1.00E+4nMAssay Description:BSA, ATP, NADH, PEP, and DTT solutions were thawed at room temperature, then transferred to ice. Pellet-frozen myofibrils (approximately twice the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2024
Entry Details
Go to US Patent

TargetDystrophin(Human)
Edgewise Therapeutics

US Patent
LigandPNGBDBM645221(US11873290, Compound 56 | 2-((3- (methoxymethyl)is...)
Affinity DataIC50: 1.00E+5nMAssay Description:Following example 15, the counter screen was done using frozen myofibril pellets obtained from cardiac tissue. The assay was done in the same manner ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2024
Entry Details
Go to US Patent