BDBM645219 2-((5-fluoropyridin-3- yl)methyl)-6-(2-(2- (trifluoromethyl)pyrrolidin- l-yl)pyrimidin-5- yl)pyridazin-3(2H)-one::US11873290, Compound 54

SMILES Fc1cncc(Cn2nc(ccc2=O)-c2cnc(nc2)N2CCCC2C(F)(F)F)c1

InChI Key InChIKey=IAWUUONTRCRAQG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 645219   

TargetDystrophin(Human)
Edgewise Therapeutics

US Patent
LigandPNGBDBM645219(US11873290, Compound 54 | 2-((5-fluoropyridin-3- y...)
Affinity DataIC50: 1.00E+4nMAssay Description:BSA, ATP, NADH, PEP, and DTT solutions were thawed at room temperature, then transferred to ice. Pellet-frozen myofibrils (approximately twice the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2024
Entry Details
Go to US Patent

TargetDystrophin(Human)
Edgewise Therapeutics

US Patent
LigandPNGBDBM645219(US11873290, Compound 54 | 2-((5-fluoropyridin-3- y...)
Affinity DataIC50: 1.00E+5nMAssay Description:Following example 15, the counter screen was done using frozen myofibril pellets obtained from cardiac tissue. The assay was done in the same manner ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2024
Entry Details
Go to US Patent