BDBM645206 2-((5-(pyridin-3-yl)- 1,3,4-thiadiazol-2- yl)methyl)-6-(2-(2,2,2- trifluoroethoxy)pyrimidin- 5-yl)pyridazin-3(2H)-one::US11873290, Compound 40

SMILES FC(F)(F)COc1ncc(cn1)-c1ccc(=O)n(Cc2nnc(s2)-c2cccnc2)n1

InChI Key InChIKey=CBWFWHQWVQAUPP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 645206   

TargetDystrophin(Human)
Edgewise Therapeutics

US Patent
LigandPNGBDBM645206(US11873290, Compound 40 | 2-((5-(pyridin-3-yl)- 1,...)
Affinity DataIC50: 1.00E+4nMAssay Description:BSA, ATP, NADH, PEP, and DTT solutions were thawed at room temperature, then transferred to ice. Pellet-frozen myofibrils (approximately twice the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2024
Entry Details
Go to US Patent

TargetDystrophin(Human)
Edgewise Therapeutics

US Patent
LigandPNGBDBM645206(US11873290, Compound 40 | 2-((5-(pyridin-3-yl)- 1,...)
Affinity DataIC50: 1.00E+5nMAssay Description:Following example 15, the counter screen was done using frozen myofibril pellets obtained from cardiac tissue. The assay was done in the same manner ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2024
Entry Details
Go to US Patent