BDBM645203 US11873290, Compound 37::ethyl 5-((6-oxo-3-(2- (2,2,2-trifluoroethoxy)pyrimidin- 5-yl)pyridazin-1(6H)-yl)methyl) isoxazole-3-carboxylate

SMILES CCOC(=O)c1cc(Cn2nc(ccc2=O)-c2cnc(OCC(F)(F)F)nc2)on1

InChI Key InChIKey=COFRXPRXDBGJCD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 645203   

TargetDystrophin(Human)
Edgewise Therapeutics

US Patent
LigandPNGBDBM645203(US11873290, Compound 37 | ethyl 5-((6-oxo-3-(2- (2...)
Affinity DataIC50: 1.00E+4nMAssay Description:BSA, ATP, NADH, PEP, and DTT solutions were thawed at room temperature, then transferred to ice. Pellet-frozen myofibrils (approximately twice the re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2024
Entry Details
Go to US Patent

TargetDystrophin(Human)
Edgewise Therapeutics

US Patent
LigandPNGBDBM645203(US11873290, Compound 37 | ethyl 5-((6-oxo-3-(2- (2...)
Affinity DataIC50: 1.00E+5nMAssay Description:Following example 15, the counter screen was done using frozen myofibril pellets obtained from cardiac tissue. The assay was done in the same manner ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2024
Entry Details
Go to US Patent