BDBM645030 US11981682, Example 12::US20240010658, Example 12

SMILES F[C@@]12CN(C[C@@H]1CC[C@H]2Nc1ccc(Cl)nn1)C(=O)c1cc2COCCc2s1

InChI Key InChIKey=XYIBGJVALJSVMZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 645030   

TargetMonoacylglycerol lipase ABHD6 [33-337](Human)
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645030(US20240010658, Example 12 | US11981682, Example 12)
Affinity DataIC50: 1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/4/2024
Entry Details
Go to US Patent

TargetMonoacylglycerol lipase ABHD6(Human)
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645030(US20240010658, Example 12 | US11981682, Example 12)
Affinity DataIC50: 1nMAssay Description:First, 1-arachidonoyl glycerol (Cayman Chemical) as a substrate was prepared with an assay buffer containing 50 mM tris-HCl (pH 7.4), 100 mM NaCl, an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
Go to US Patent

TargetMonoacylglycerol lipase ABHD6(Human)
Ono Pharmaceutical Co.

US Patent
LigandPNGBDBM645030(US20240010658, Example 12 | US11981682, Example 12)
Affinity DataIC50: 1nMAssay Description:The binding affinity of the test compound for human ABHD6 was measured using bioluminescence resonance energy transfer (hereinafter, abbreviated as B...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2024
Entry Details
Go to US Patent