BDBM644578 5-((2-(4-((3- (furan-3- ylmethyl)-5- (trifluoromethoxy) benzyl)amino) butoxy)ethyl) amino)benzo [c][2,6] naphthyridine- 8-carboxamide::US11866436, Example 173

SMILES NC(=O)c1ccc2c(c1)nc(NCCOCCCCNCc1cc(Cc3ccoc3)cc(OC(F)(F)F)c1)c1ccncc21

InChI Key InChIKey=JKZSWHYFSJQUBI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 644578   

TargetCasein kinase II subunit alpha [2-329](Human)
Cambridge Enterprise

US Patent
LigandPNGBDBM644578(5-((2-(4-((3- (furan-3- ylmethyl)-5- (trifluoromet...)
Affinity DataIC50: 0.223nMAssay Description:Final assay conditions comprised 0.2 nM CK2α, 50 μM peptide substrate (RRRADDSDDDDD), 15 μM ATP in 1× reaction buffer (40 mM Tris pH7....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
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TargetDual specificity protein kinase CLK2(Human)
Cambridge Enterprise

US Patent
LigandPNGBDBM644578(5-((2-(4-((3- (furan-3- ylmethyl)-5- (trifluoromet...)
Affinity DataIC50: 2.05E+3nMAssay Description:The assay was conducted in the same way as described for CK2α, with final assay conditions comprising 20 nM CLK2 (Carna Biosciences-04-127), 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
Go to US Patent