BDBM644507 5-(3-(4-((3- chloro-5- (cyanomethyl) benzyl)amino) butoxy) azetidin-1-yl) benzo[c][2,6] naphthyridine- 8-carboxylic acid::US11866436, Example 102

SMILES OC(=O)c1ccc2c(c1)nc(N1CC(C1)OCCCCNCc1cc(Cl)cc(CC#N)c1)c1ccncc21

InChI Key InChIKey=HLJDNMVEJYCKAW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 644507   

TargetCasein kinase II subunit alpha [2-329](Human)
Cambridge Enterprise

US Patent
LigandPNGBDBM644507(US11866436, Example 102 | 5-(3-(4-((3- chloro-5- (...)
Affinity DataIC50: 0.324nMAssay Description:Final assay conditions comprised 0.2 nM CK2α, 50 μM peptide substrate (RRRADDSDDDDD), 15 μM ATP in 1× reaction buffer (40 mM Tris pH7....More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
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TargetDual specificity protein kinase CLK2(Human)
Cambridge Enterprise

US Patent
LigandPNGBDBM644507(US11866436, Example 102 | 5-(3-(4-((3- chloro-5- (...)
Affinity DataIC50: 69.5nMAssay Description:The assay was conducted in the same way as described for CK2α, with final assay conditions comprising 20 nM CLK2 (Carna Biosciences-04-127), 50 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
Go to US Patent