BDBM644332 6-chloro-4-{4-[(5-fluoro-2-hydroxyphenyl)methyl]piperazin-1-yl}-1-methyl-2-oxo-1,2-dihydro-1,5-naphthyridine-3-carbonitrile::US11866430, Example 312

SMILES Cn1c2ccc(Cl)nc2c(N2CCN(Cc3cc(F)ccc3O)CC2)c(C#N)c1=O

InChI Key InChIKey=VIOGUTCTBXMZDQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 644332   

TargetDiacylglycerol kinase alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM644332(US11866430, Example 312 | 6-chloro-4-{4-[(5-fluoro...)
Affinity DataIC50: 120nMAssay Description:The compound inhibition studies were carried out as follows: 50 nL droplets of each test compound (top concentration 10 mM with 11 point, 3-fold dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
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TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM644332(US11866430, Example 312 | 6-chloro-4-{4-[(5-fluoro...)
Affinity DataIC50: 2.40E+5nMAssay Description:The compound inhibition studies were carried out as follows: 50 nL droplets of each test compound (top concentration 10 mM with 11 point, 3-fold dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
Go to US Patent