BDBM644291 8-{4-[(4-chloro-2-hydroxyphenyl)methyl]piperazin-1-yl}-5-methyl-6-oxo-5,6-dihydro-1,5-naphthyridine-2,7-dicarbonitrile::US11866430, Example 269

SMILES Cn1c2ccc(nc2c(N2CCN(Cc3ccc(Cl)cc3O)CC2)c(C#N)c1=O)C#N

InChI Key InChIKey=SAJCGYYONJEBLE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 644291   

TargetDiacylglycerol kinase alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM644291(US11866430, Example 269 | 8-{4-[(4-chloro-2-hydrox...)
Affinity DataIC50: 52nMAssay Description:The compound inhibition studies were carried out as follows: 50 nL droplets of each test compound (top concentration 10 mM with 11 point, 3-fold dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
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TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM644291(US11866430, Example 269 | 8-{4-[(4-chloro-2-hydrox...)
Affinity DataIC50: 2.60E+4nMAssay Description:The compound inhibition studies were carried out as follows: 50 nL droplets of each test compound (top concentration 10 mM with 11 point, 3-fold dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
Go to US Patent