BDBM644152 8-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-5-methyl-7-nitro-6-oxo-5,6-dihydro-1,5-naphthyridine-2-carbonitrile::US11866430, Example 40::US20240108654, Compound 15
SMILES Cn1c2ccc(nc2c(N2CCN(CC2)C(c2ccc(F)cc2)c2ccc(F)cc2)c([N+]([O-])=O)c1=O)C#N
InChI Key InChIKey=XAHMIJCNFUSTMT-UHFFFAOYSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 644152
Affinity DataIC50: 1.90E+3nMAssay Description:The compound inhibition studies were carried out as follows: 50 nL droplets of each test compound (top concentration 10 mM with 11 point, 3-fold dilu...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:The compound inhibition studies were carried out as follows: 50 nL droplets of each test compound (top concentration 10 mM with 11 point, 3-fold dilu...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:The DGKα and DGKζ reactions were performed using either extruded liposome (DGKα and DGKζ LIPGLO assays) or detergent/lipid micell...More data for this Ligand-Target Pair
Affinity DataIC50: 210nMAssay Description:The DGKα and DGKζ reactions were performed using either extruded liposome (DGKα and DGKζ LIPGLO assays) or detergent/lipid micell...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human DGK alpha using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
TargetDiacylglycerol kinase beta(Human)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human DGK beta using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
TargetDiacylglycerol kinase gamma(Human)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 680nMAssay Description:Inhibition of human DGK gamma using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
TargetDiacylglycerol kinase kappa(Homo sapiens)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of human DGK kappa using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human DGK zeta using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetDiacylglycerol kinase iota(Homo sapiens)
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Bristol Myers Squibb Research and Early Development
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human DGK iota using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo kinase assayMore data for this Ligand-Target Pair