BDBM644118 4-(4-(bis(4-fluorophenyl)methyl)piperazin-1-yl)-1-methyl-3-nitro-1,5-naphthyridin-2(1H)-one::US11866430, Example 3

SMILES Cn1c2cccnc2c(N2CCN(CC2)C(c2ccc(F)cc2)c2ccc(F)cc2)c([N+]([O-])=O)c1=O

InChI Key InChIKey=KZJLLMSZJHWBHD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 644118   

TargetDiacylglycerol kinase alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM644118(US11866430, Example 3 | 4-(4-(bis(4-fluorophenyl)m...)
Affinity DataIC50: 2.10E+3nMAssay Description:The compound inhibition studies were carried out as follows: 50 nL droplets of each test compound (top concentration 10 mM with 11 point, 3-fold dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
Go to US Patent

TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM644118(US11866430, Example 3 | 4-(4-(bis(4-fluorophenyl)m...)
Affinity DataIC50: 2.40E+5nMAssay Description:The compound inhibition studies were carried out as follows: 50 nL droplets of each test compound (top concentration 10 mM with 11 point, 3-fold dilu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2024
Entry Details
Go to US Patent

TargetDiacylglycerol kinase alpha(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM644118(US11866430, Example 3 | 4-(4-(bis(4-fluorophenyl)m...)
Affinity DataIC50: 53nMAssay Description:Inhibition of human DGK alpha using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDiacylglycerol kinase zeta(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM644118(US11866430, Example 3 | 4-(4-(bis(4-fluorophenyl)m...)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human DGK zeta using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed
TargetDiacylglycerol kinase iota(Homo sapiens)
Bristol Myers Squibb Research and Early Development

Curated by ChEMBL
LigandPNGBDBM644118(US11866430, Example 3 | 4-(4-(bis(4-fluorophenyl)m...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human DGK iota using 1, 2-Dilauroyl-sn-glycerol as substrate by ADP-Glo kinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2024
Entry Details
PubMed