BDBM643756 (4S)-7-chloro-6-(2,6-difluorophenyl)-8-ethyl-1,4-dimethyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine::US20240002393, Example 109

SMILES CCc1ccc-2c(c1Cl)C(=N[C@@H](C)c1nnc(C)n-21)c1c(F)cccc1F

InChI Key InChIKey=CPWJDGKKDQPBKJ-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 643756   

LigandPNGBDBM643756((4S)-7-chloro-6-(2,6-difluorophenyl)-8-ethyl-1,4-d...)
Affinity DataKi:  3.70nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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Date in BDB:
2/28/2024
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LigandPNGBDBM643756((4S)-7-chloro-6-(2,6-difluorophenyl)-8-ethyl-1,4-d...)
Affinity DataKi:  65.8nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
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LigandPNGBDBM643756((4S)-7-chloro-6-(2,6-difluorophenyl)-8-ethyl-1,4-d...)
Affinity DataKi:  754nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
Go to US Patent