BDBM643754 (4S)-7-chloro-6-(2,6-difluorophenyl)-4-methyl-8-(trifluoromethyl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine::US20240002393, Example 107

SMILES C[C@@H]1N=C(c2c(F)cccc2F)c2c(Cl)c(ccc2-n2cnnc12)C(F)(F)F

InChI Key InChIKey=WFSSRJNOEZEXCS-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 643754   

LigandPNGBDBM643754((4S)-7-chloro-6-(2,6-difluorophenyl)-4-methyl-8-(t...)
Affinity DataKi:  3nMAssay Description:Table 1: Radioligand binding assays were carried out in a volume of 200 μL (96-well plates) which contained 100 μL of cell membranes, [3H]F...More data for this Ligand-Target Pair
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Date in BDB:
2/28/2024
Entry Details
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LigandPNGBDBM643754((4S)-7-chloro-6-(2,6-difluorophenyl)-4-methyl-8-(t...)
Affinity DataKi:  68.3nMAssay Description:Table 2: Electrophysiological experiments were performed using the Roboocyte instrument (MultiChannelSystems, Reutlingen, Germany) on days 3 to 5 aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
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LigandPNGBDBM643754((4S)-7-chloro-6-(2,6-difluorophenyl)-4-methyl-8-(t...)
Affinity DataKi:  3.53E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2024
Entry Details
Go to US Patent